Sibutramine is a nonsteroidal anorexigenic drug that increases the feeling of satiety. The drug is a direct inhibitor of serotonin and norepinephrine reuptake, structurally similar to amphetamine. It belongs to a group of medications for the treatment of obesity and is used in the comprehensive maintenance treatment of overweight patients. Sibutramine hydrochloride was launched on the market in 1998 under the brand name Meridia, by Abbott Laboratories.
Sibutramine works in two ways:
It inhibits the reuptake of the neurotransmitters serotonin and norepinephrine in the interstitial space, which reduces appetite and food intake (increases the feeling of satiety). In studies, patients who underwent the treatment reduced their daily intake by 1,300 calories.
It stimulates metabolism and increases thermogenesis. This fat-burning effect occurs due to an indirect impact on beta-3-adrenergic receptors, which are responsible for fat burning.
Sibutramine is converted by the liver into metabolites that significantly surpass sibutramine itself in their ability to inhibit the reuptake of serotonin and norepinephrine.
Chemical name 1-[1-(4-Chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Formula C17H26ClN
Anabolic activity index is not a steroid.
Androgenic activity index is not a steroid.
Sibutramine is a nonsteroidal anorexigenic drug that increases the feeling of satiety. The drug is a direct inhibitor of serotonin and norepinephrine reuptake, structurally similar to amphetamine. It belongs to a group of medications for the treatment of obesity and is used in the comprehensive maintenance treatment of overweight patients. Sibutramine hydrochloride was launched on the market in 1998 under the brand name Meridia, by Abbott Laboratories.
Sibutramine works in two ways:
It inhibits the reuptake of the neurotransmitters serotonin and norepinephrine in the interstitial space, which reduces appetite and food intake (increases the feeling of satiety). In studies, patients who underwent the treatment reduced their daily intake by 1,300 calories.
It stimulates metabolism and increases thermogenesis. This fat-burning effect occurs due to an indirect impact on beta-3-adrenergic receptors, which are responsible for fat burning.
Sibutramine is converted by the liver into metabolites that significantly surpass sibutramine itself in their ability to inhibit the reuptake of serotonin and norepinephrine.
Chemical name 1-[1-(4-Chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Formula C17H26ClN
Anabolic activity index is not a steroid.
Androgenic activity index is not a steroid.