MGF (mechanical growth factor) has been used by bodybuilders and athletes for several years. After resistance exercise, IGF-1 is released into the muscle. Specifically, at this moment, immediately after the mechanical use of a muscle, the IGF-I gene binds to MGF, which initiates hypertrophy and repair of local muscle damage. It does this through the activation of muscle stem cells and satellite cells, but also through various other anabolic processes. It differs from "normal" IGF-1 mainly due to its C-terminal sequence. In a rodent study, a single intramuscular injection into the muscle resulted in a 25% increase in the average cross-sectional area of the muscle fiber within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase. It also appears that, with regard to age, younger people have a better ability to respond to MGF, and that older people experience a diminished response to MGF, resulting in a decreased ability to stimulate the growth of new muscle tissue. For research purposes only.
MGF (mechanical growth factor) has been used by bodybuilders and athletes for several years. After resistance exercise, IGF-1 is released into the muscle. Specifically, at this moment, immediately after the mechanical use of a muscle, the IGF-I gene binds to MGF, which initiates hypertrophy and repair of local muscle damage. It does this through the activation of muscle stem cells and satellite cells, but also through various other anabolic processes. It differs from "normal" IGF-1 mainly due to its C-terminal sequence. In a rodent study, a single intramuscular injection into the muscle resulted in a 25% increase in the average cross-sectional area of the muscle fiber within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase. It also appears that, with regard to age, younger people have a better ability to respond to MGF, and that older people experience a diminished response to MGF, resulting in a decreased ability to stimulate the growth of new muscle tissue. For research purposes only.