DO NOT USE IF YOU ARE PREGNANT OR MAY BECOME PREGNANT.
Isotretinoin (also known as Roaccutane or 13-cis-retinoic acid) is an oral medication primarily used to treat acne. Isotretinoin increases the production of neutrophil gelatinase-associated lipocalin (NGAL) in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells, as well as exhibiting an antimicrobial effect on Propionibacterium acnes. The medication decreases the size and sebum production of sebaceous glands. The most common adverse effects are transient worsening of acne (lasting 2 to 3 weeks), chapped lips, dry and fragile skin, and increased susceptibility to sunburn. In very rare cases, it has also been used to prevent certain types of skin cancer and treat others. It is used to treat harlequin ichthyosis, a usually fatal skin disease, and lamellar ichthyosis. Isotretinoin is a retinoid, meaning it is related to vitamin A and is found naturally in small amounts in the body.
RECOMMENDATION: Oral isotretinoin is better absorbed when taken with a high-fat meal due to its high lipophilicity. The effectiveness of isotretinoin doubles when taken after a high-fat meal compared to when taken on an empty stomach.
WARNING: Due to the relationship between the molecular structure of isotretinoin and vitamin A, it should not be taken with vitamin A supplements due to the risk of cumulative overdose toxicity.
WARNING: Isotretinoin is known to cause birth defects due to intrauterine exposure, because of the molecule's strong resemblance to retinoic acid, a natural derivative of vitamin A that controls normal embryonic development. There is approximately a 20% to 35% risk of birth defects in babies exposed to the drug in utero, and approximately 30% to 60% of children exposed to isotretinoin during gestation exhibit neurocognitive impairment.
DO NOT USE ROAS IF YOU ARE PREGNANT OR COULD BECOME PREGNANT
DO NOT USE IF YOU ARE PREGNANT OR MAY BECOME PREGNANT.
Isotretinoin (also known as Roaccutane or 13-cis-retinoic acid) is an oral medication primarily used to treat acne. Isotretinoin increases the production of neutrophil gelatinase-associated lipocalin (NGAL) in the skin, which has been shown to reduce sebum production by inducing apoptosis in sebaceous gland cells, as well as exhibiting an antimicrobial effect on Propionibacterium acnes. The medication decreases the size and sebum production of sebaceous glands. The most common adverse effects are transient worsening of acne (lasting 2 to 3 weeks), chapped lips, dry and fragile skin, and increased susceptibility to sunburn. In very rare cases, it has also been used to prevent certain types of skin cancer and treat others. It is used to treat harlequin ichthyosis, a usually fatal skin disease, and lamellar ichthyosis. Isotretinoin is a retinoid, meaning it is related to vitamin A and is found naturally in small amounts in the body.
RECOMMENDATION: Oral isotretinoin is better absorbed when taken with a high-fat meal due to its high lipophilicity. The effectiveness of isotretinoin doubles when taken after a high-fat meal compared to when taken on an empty stomach.
WARNING: Due to the relationship between the molecular structure of isotretinoin and vitamin A, it should not be taken with vitamin A supplements due to the risk of cumulative overdose toxicity.
WARNING: Isotretinoin is known to cause birth defects due to intrauterine exposure, because of the molecule's strong resemblance to retinoic acid, a natural derivative of vitamin A that controls normal embryonic development. There is approximately a 20% to 35% risk of birth defects in babies exposed to the drug in utero, and approximately 30% to 60% of children exposed to isotretinoin during gestation exhibit neurocognitive impairment.
DO NOT USE ROAS IF YOU ARE PREGNANT OR COULD BECOME PREGNANT