Pharmacological category:
Anabolic androgenic steroid
Mechanism of action of the drug:
Methandienone acts by binding to and activating the androgen receptor (AR), resulting in significant increases in protein synthesis, glycogenolysis, and muscle strength in a short period of time. Although it can be converted into a more potent anabolic-androgenic steroid (AAS), methyl-1-testosterone (17α-methyl-δ1-DHT), by the enzyme 5α-reductase, the drug has minimal affinity for this enzyme and therefore produces only insignificant amounts of methyl-1-testosterone. Consequently, drugs such as finasteride and dutasteride, which are 5α-reductase inhibitors, are ineffective in reducing the androgenic effects of methandienone.
Side effects:
Oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization are possible androgenic side effects. Gynecomastia and fluid retention are two estrogen-related side effects that may develop. There are case reports of gynecomastia. Methandienone, like other 17-alkylated steroids, carries a risk of hepatotoxicity and, if used for a prolonged period without proper precautions, can cause liver damage.
Dosage:
The lowest dose of methandienone found is 15 mg on average. Users with prior experience with methandienone tend to increase the dose by 5 to 10 mg with each cycle. Even for the most experienced users, it is not recommended to exceed 50 mg of methandienone due to the rapid increase in the intensity of side effects.
Pharmacological category:
Anabolic androgenic steroid
Mechanism of action of the drug:
Methandienone acts by binding to and activating the androgen receptor (AR), resulting in significant increases in protein synthesis, glycogenolysis, and muscle strength in a short period of time. Although it can be converted into a more potent anabolic-androgenic steroid (AAS), methyl-1-testosterone (17α-methyl-δ1-DHT), by the enzyme 5α-reductase, the drug has minimal affinity for this enzyme and therefore produces only insignificant amounts of methyl-1-testosterone. Consequently, drugs such as finasteride and dutasteride, which are 5α-reductase inhibitors, are ineffective in reducing the androgenic effects of methandienone.
Side effects:
Oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization are possible androgenic side effects. Gynecomastia and fluid retention are two estrogen-related side effects that may develop. There are case reports of gynecomastia. Methandienone, like other 17-alkylated steroids, carries a risk of hepatotoxicity and, if used for a prolonged period without proper precautions, can cause liver damage.
Dosage:
The lowest dose of methandienone found is 15 mg on average. Users with prior experience with methandienone tend to increase the dose by 5 to 10 mg with each cycle. Even for the most experienced users, it is not recommended to exceed 50 mg of methandienone due to the rapid increase in the intensity of side effects.