Clomiphene 50mg 100 tablets

Clomos (active ingredient:  clomiphene citrate) is a non-steroidal selective estrogen receptor modulator (SERM) from the triphenylethylene group. Clomiphene was developed and approved for use in the early 1970s for the treatment of female infertility, and its use was subsequently expanded to the treatment of male infertility.

In most cases, this SERM is used for post-cycle therapy (PCT), which aims to stimulate the natural production of testosterone suppressed by the use of anabolic steroids. Clomiphene stimulates the hypothalamus, which in turn stimulates the anterior pituitary gland to release gonadotropic hormones. The gonadotropic hormones are follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH stimulates (in men) spermatogenesis, and LH stimulates the Leydig cells of the testes to secrete more testosterone. This feedback mechanism is known as the hypothalamic-pituitary-testicular (HPT) axis and results in increased endogenous testosterone production. Blood levels increase to compensate for the decrease in exogenous steroid levels. This is vital to minimize muscle mass loss after the cycle.

Clomiphene, like all triphenylethylene compounds in the SERM family (tamoxifen, clomiphene, and toremifene), also exhibits estrogen agonist effects. Clomiphene, being a SERM, does not reduce circulating estradiol levels in the blood, but rather occupies receptor sites, preventing estrogen itself from binding to these receptors due to clomiphene's higher binding affinity. Therefore, clomiphene binds to estrogen receptors on cells, blocking estrogen entry into the bloodstream. However, it is important to note that clomiphene has significantly lower efficacy compared to tamoxifen regarding its estrogen antagonist activity in breast tissue.

The average starting dose of clomiphene should be around 150 mg per day, maintained at this level for 1 to 2 weeks. From there, the dose should be reduced to 100 mg for another 1 to 2 weeks, with the final dose dropping to 25-50 mg per day in the last week of PCT (Post Cycle Therapy). Exact dosages vary from person to person and should be determined based on blood test results.

RECOMMENDATION:  The correct time to start clomiphene depends on the type and cycle of steroids you used. Different steroids have different half-lives (indicating the time it takes for a substance to dissipate in the blood), and clomiphene administration should be done accordingly. If your cycle ended with a long-ester steroid, the initial dose of Clomos should begin approximately two weeks after the last injection; if it ended with short-ester steroids, PCT (Post Cycle Therapy) will begin about three days after the last injection. Taking clomiphene when androgen levels in the blood are still high will be a waste. It is crucial to wait for androgen levels to decrease before starting post-cycle therapy. However, if taken too late, you may lose muscle mass.

There are no special considerations regarding the administration of clomiphene. It can be administered before, during, or after meals. It can also be taken in the morning or at night, before bedtime. There is no need to split the clomiphene dose throughout the day, as its half-life is approximately 5 days, which is considered sufficient to maintain stable blood levels for a period of 24 hours (or more) without the need to split tablets or doses.

• Chemical name 2-(4-(2-chloro-1,2-diphenylthenyl)phenoxy)-N,N-diethyl-ethanamine

• Formula C26H28ClNO

• Anabolic activity index is not a steroid.

• Androgenic activity index is not a steroid.